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Lancet Diabetes Endocrinol 2021;9:755-66.ArticlePubMed 56
Finally, long-standing diabetes patients require an exogenous insulin injection to sustain high-insulin concentration, which is the so-called exogenous hyperinsulinemia. Moreover, a unique portal structure enables insulin secreted from the pancreatic islet to perfuse the exocrine pancreas first, significantly increasing the regional insulin concentration in PDA tissue
GI distress lowers nutrient absorption and discourages eating
PMCID: PMC8826179
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